LYMPHOID NEOPLASIA Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features
نویسندگان
چکیده
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features Abdel Kareem Azab,1 Jinsong Hu,2 Phong Quang,1 Feda Azab,1 Costas Pitsillides,3 Rana Awwad,4 Brian Thompson,3 Patricia Maiso,1 Jessica D. Sun,5 Charles P. Hart,5 Aldo M. Roccaro,1 Antonio Sacco,1 Hai T. Ngo,1 Charles P. Lin,3 Andrew L. Kung,6 Ruben D. Carrasco,1 Karin Vanderkerken,2 and Irene M. Ghobrial1
منابع مشابه
Hypoxia promotes dissemination of multiple myeloma through acquisition of epithelial to mesenchymal transition-like features.
The spread of multiple myeloma (MM) involves (re)circulation into the peripheral blood and (re)entrance or homing of MM cells into new sites of the BM. Hypoxia in solid tumors was shown to promote metastasis through activation of proteins involved in the epithelial-mesenchymal transition (EMT) process. We hypothesized that MM-associated hypoxic conditions activate EMT-related proteins and promo...
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